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Pacifico was born into a distinguished family in San Severino in the Marche of Ancona in central Italy. After joining the Friars Minor, he was ordained. He taught philosophy for two years and then began a successful preaching career.

Pacifico was an ascetic man. He fasted perpetually, eating no more than bread, soup or water. His "hair shirt" was made of iron. Poverty and obedience were two virtues for which his confreres especially remembered him.

At the age of 35, Pacifico contracted an illness that eventually left him deaf, blind and crippled. He offered his sufferings for the conversion of sinners, and he cured many of the sick who came to him. Pacifico also served as the superior of the friary in San Severino. He was canonized in 1839.